Spell Shields won't block the damage from Deadly Venom, but they will block the effects Twitch can trigger with it.
If you suspect Twitch has left the lane, let your teammates know that Twitch is ''MIA.''
Twitch is fragile. Work with teammates to focus on him when you're able to catch him out of Camouflage.
The stat comparisons shown on this page clarify several critical Sett against Twitch counter statistics that can help us realize the distinctions between this set of champions. For instance, Sett’s KDA ratio ([kills + assists] / deaths) of NaN is more than Twitch’s ratio of NaN, indicating that Sett may be more central to his team's team fighting capacity than Twitch..
Sett usually has a slightly smaller longest killing spree than his foe does. On average, he receives more damage than Twitch. This typically indicates different amounts of tankyness, yet it can also hint that the one champion has less agility and thus is unable to flee from further damage when engaged or poked.
Both League of Legends champs are great champions. Both have their strengths, weaknesses, and counters. In the game's current meta, Sett usually fairs equally well when facing off against Twitch, with a 50.1% win rate. As a result, Sett makes an ok counter for Twitch.
While Sett does have a higher winrate than Twitch, when on opposite teams, Sett also has a much lower level of difficulty that makes him a less difficult character to develop with. You should be careful when picking Sett into Twitch.
Furthermore, Sett has almost no amount of CC and other utility, a similar amount to Twitch. This often makes her just as valuable during team fights, especially when facing champions with a lot of burst damage.
While there is not a single best champion for every situation in League of Legends, in Sett vs Twitch matchups, Sett is the better champion with a similar win rate, less champion complexity, and a similar amount of utility to help out your team members during teamfights.
Sett is a decent counter for Twitch. Focus your tactics on keeping up your CS and taking out objectives. If you are able to do that, you should hold your own as Sett against Twitch.
To truly master Sett in order to counter Twitch during both the laning and mid / late game phases of League of Legends, you should continue reading to pick up a few extra lessons on this matchup. If you mind the build and tips shown here, you should increase your win rate significantly and be that much closer to League of Legends pro players.
Sett often racks up a similar amount of CS as Twitch. Champions who typically don't get much CS typically don't have to have much CS to be effective, such as support champions. These kinds of champions are capable of scaling well off of their skills, stats, and first items alone. Yet, champions with large amounts of CS, such as hyper-carries, usually need several high cost items to be effective. In either situation, try to exceed the values shown on this page to do well.
The most crucial items to have in your Sett versus Twitch build include Sterak's Gage, Blade of The Ruined King, and Titanic Hydra. When Sett incorporated at least these three pieces in his build, he performed a lot better countering Twitch than with many other common builds. In fact, Sett boasted an average win rate of 50.1% battling Twitch with this counter build.
To have the greatest chance of vanquishing Twitch as Sett, you should equip the Conqueror, Triumph, Legend: Alacrity, Last Stand, Second Wind, and Unflinching runes from the Precision and Resolve rune sets. Of all the rune builds players chose for Sett vs Twitch matchups, this mix of runes resulted in the greatest win rate. In fact, these runes provided a 50.1% winrate overall.
By default, tips, stats, and builds on how to beat Twitch as Sett are displayed for all ranked divisions combined. If you would like to narrow the statistics and builds to a specific rank, you should use the selection menu above.