To maximize your ultimate's damage use it when there are many spheres on the battlefield.
After you hit an enemy champion with Force of Will follow up with Dark Sphere, they'll be slowed and have a hard time avoiding it.
Get one of your spells to rank 5 as quickly as possible, they gain powerful bonus effects at max rank.
Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stat comparisons provided here feature some significant Syndra versus Karthus counter statistics that may help you appreciate the distinctions between the two. As an example, Syndra’s KDA ratio ([kills + assists] / deaths) of NaN is better than Karthus’s ratio of NaN, indicating that Syndra may be more central to her team's team fighting potential than Karthus..
Syndra normally has a similar longest kill spree as her counter does. On average, she receives less damage than Karthus. This often reflects differing health capacities, but it can also indicate that the one champion has less mobility and thus is unable to flee from additional harm when poked or engaged.
Both League champs are great. Both champs have their pros and cons. In League's current meta, Syndra usually fairs equally well when playing against Karthus, with a 50.9% win rate. As a result, Syndra makes an ok counter for Karthus.
While Syndra does have a higher win rate compared to Karthus, when on opposite teams, Syndra also has a greater difficulty level that makes her a more complex character to develop with. You still need to be cautious when picking Syndra into Karthusas her relative depth means you may not be able to reach her full potential without a lot of practice beforehand.
Moreover, Syndra has a good amount of utility and CC, a similar amount to Karthus. This makes her just as valuable during teamfights, especially when trying to counter champions with a ton of burst damage.
While there is not a single best champion overall in League of Legends, in Syndra vs Karthus matchups, Syndra is the better champion with a similar win rate, more champion depth, and a similar amount of utility to help out your allies during team fights.
Syndra is a decent counter to Karthus. You will do well by focussing your actions on keeping up your gold income and clearing objectives. If you are able to do that, you should hold your own as Syndra against Karthus.
To learn all of the intricacies of Syndra in order to counter Karthus during both the early game and mid / late game phases of League of Legends, you should continue reading to gather a few extra tricks and insights into this matchup. If you mind the build and suggestions shown above, you will grow your win rate significantly and be that much closer to League of Legends pro players.
Syndra most often gets more CS as Karthus. Champs who typically don't take many minion kills usualy don't have to have much CS to be effective, such as sup champs. These kinds of champions are capable of scaling well off of their skills, stats, and first items alone. Yet, champions with a lot of CS, such as hyper-carries, often have to have several high cost items to be effective. In either case, try to surpass the values shown here to do well.
The best items to have in your Syndra versus Karthus build include Rabadon's Deathcap, Shadowflame, and Luden's Companion. When Syndra combined at least these three items in her build, she did much better when fighting Karthus than with many other common builds. In fact, Syndra boasted an average win rate of 50.9% when countering Karthus with this build.
To have the greatest likelihood of annihilating Karthus as Syndra, you should equip the First Strike, Magical Footwear, Minion Dematerializer, Cosmic Insight, Manaflow Band, and Transcendence runes from the Inspiration and Sorcery rune sets. Of all the runes we have analyed for Syndra vs Karthus counters, this composite of runes resulted in the greatest win rate. In fact, these runes averaged a 50.9% winrate overall.
By default, tips, statistics, and builds on how to beat Karthus as Syndra are displayed for every ranked division. If you want to filter the statistics and builds to a distinct skill level, you should use the selection menu earlier in the counter matchup guide.