Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Kai'Sa is very vulnerable to getting outranged by mages and long range carries.
Make sure to place wards in your blind spots so you can see Kai'Sa coming.
Kai'Sa is very good at picking off isolated enemies. Stick together against her.
The stat comparisons shown here underscore several vital Vayne against Kai'Sa matchup statistics that can help us understand the differences and similarities between the two. As an example, Vayne’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Kai'Sa’s KDA ratio of NaN, demonstrating that Vayne may be more central to her team's team fighting effectiveness than Kai'Sa..
Vayne usually has a similar longest kill spree as her enemy does. On average, she receives a similar amount of damage to Kai'Sa. This often reflects differing health capacities, but it can also illustrate that the champion with increased HP has less agility and thus is unable to kite away from further damage when engaged or poked.
Both LoL champions are great champions. Both have their strengths, weaknesses, and counters. In the game's current meta, Vayne usually wins when taking on Kai'Sa, with a 54.2% win rate. Therefore, Vayne makes a great counter to Kai'Sa.
While Vayne does have a much higher winrate than Kai'Sa, when they face off with one another, Vayne also has a greater learning curve that makes her a more complex champ to develop with. You should be be fine when picking Vayne into Kai'Saas her relative depth means you may not be able to unleash her full potential without a significant amount of practice beforehand.
Additionally, Vayne has some amount of utility and CC, a similar amount to Kai'Sa. This makes her just as valuable during teamfights, especially when facing champions with a lot of burst damage.
While there isn't a single best champion overall in League of Legends, in Vayne vs Kai'Sa matchups, Vayne is the better champion with a noticably higher win rate, more champion depth, and a similar amount of utility to help out your team members during late stage team fights.
Vayne is a great counter for Kai'Sa. You will do well by focussing your actions on keeping up your gold income and clearing objectives. If you do that, you should do very well as Vayne against Kai'Sa.
To truly master Vayne to counter Kai'Sa during both the early game and mid / late game phases of League of Legends, you should keep reading to gather a few extra lessons on this matchup. If you pay attention to the build and stats displayed above, you will increase your win rate by a lot and be closer to League of Legends pro players.
Vayne most often accumulates a similar amount of CS relative to Kai'Sa. Champs who on average don't get much CS often don't need much CS to be effective, such as supports. These kinds of champions are able to scale properly off of their skills, stats, and first items alone. Yet, champions with a lot of CS, such as hyper-carries, typically have to have several high cost items to be effective. In either situation, try to surpass the numbers displayed on this page to do well.
The most important items to use in your Vayne versus Kai'Sa build consist of Experimental Hexplate, Guinsoo's Rageblade, and Terminus. When Vayne used at least these three pieces in her build, she did significantly better versus Kai'Sa than with most other typical counter builds. In fact, Vayne boasted an average winrate of 54.2% battling Kai'Sa with this build.
To have the greatest chance of crushing Kai'Sa as Vayne, you should equip the Fleet Footwork, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Out of all the runes players chose for Vayne vs Kai'Sa counters, this mix of runes yielded the highest win rate. Moreover, these runes averaged a 54.2% winrate overall.
If you would like to see Vayne x Kai'Sa tips and builds for a a distinct division rank, feel free to select one from the selection menu displayed above. By default, the stats and strategies shown are computed using every match run with these champs.