Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The stats shown on this page underscore several valuable Vayne versus Sett matchup stats that can help you understand the differences and similarities between the pair. For instance, Vayne’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Sett’s ratio of NaN, highlighting that Vayne may be more central to her team's team fighting effectiveness than Sett..
Vayne usually has a slightly larger longest killing spree than her foe does. Commonly, she takes less damage than Sett. This typically indicates differing health capacities; however, it can also indicate that the champ with increased health has less mobility and thus is not able to escape further damage when engaged or poked.
Both League of Legends champs are great. Both champs have their strengths, weaknesses, and counters. In the game's current meta, Vayne usually wins when trying to fight Sett, with a 51.2% win rate. Therefore, Vayne makes a good counter for Sett.
While Vayne does have a higher winrate compared to Sett, when facing one another, Vayne also has a much greater learning curve that makes her a more challenging champ to learn. You still need to be cautious when picking Vayne into Settas her relative depth means you may not be able to unleash her full potential without a lot of practice beforehand.
Moreover, Vayne has some amount of utility and CC, a similar amount to Sett. This often makes her just as valuable during teamfights, especially when trying to counter champions with a ton of burst damage.
While there isn't one best champion in League of Legends, in Vayne vs Sett matchups, Vayne is the better champion with a higher win rate, more champion depth, and a similar amount of utility to help out your teammates during teamfights.
Vayne is a decent counter to Sett. Focus your play on increasing your CS and clearing objectives. If you do that, you should hold your own as Vayne against Sett.
To truly master Vayne in order to counter Sett during both the laning and mid / late game phases of League of Legends, you should continue reading to pick up a few extra tips and tricks for this matchup. If you mind the build and suggestions presented above, you will grow your win rate significantly and be closer to League of Legends pro players.
Vayne usually gets a similar amount of CS compared to Sett. Champs who on average don't earn many minion kills typically don't have to have much CS to be valuable teammates, such as sup champs. They are capable of scaling well off of their skills, stats, and first items alone. Yet, champs with large amounts of CS, such as hyper-carries, often require several high cost items to be effective. In either case, try to do better than the numbers shown here to do well.
The most important items to use in your Vayne versus Sett build include Guardian Angel, Wit's End, and Blade of The Ruined King. When Vayne combined at least these three pieces in her build, she did a lot better against Sett than with most other commonly used builds. In fact, Vayne had an average winrate of 51.2% battling Sett with this build.
To have the best likelihood of beating Sett as Vayne, you should equip the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Out of all the rune builds players picked for Vayne vs Sett LoL games, this set of runes resulted in the greatest win rate. Notably, these runes averaged a 51.2% win rate overall.
By default, tips, statistics, and builds on how to beat Sett as Vayne are presented for every ranked division. If you would like to scope the statistics and builds to a particular division, you can use the selection menu located earlier in the counter matchup guide.