Picking up goo chunks is very important to staying alive.
When Cell Division is ready, try to die in a position that makes it difficult for the enemy team to kill your bloblets.
Charging Elastic Slingshot from the fog of war will give opponents less time to react.
Karthus can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.
The stat comparisons shown on this page underscore several critical Zac versus Karthus matchup statistics that may help you understand the distinctions between the two. For instance, Zac’s KDA ratio ([kills + assists] / deaths) of NaN is greater than Karthus’s ratio of NaN, showing that Zac may be more central to his team's team fighting potential than Karthus..
Zac typically has a slightly smaller longest killing spree than his opponent does. Commonly, he takes more damage than Karthus. This is usually reflective of differing health capacities; however, it can also hint that the one champ has less agility and thus is not able to flee from further harm when poked or engaged.
Both League of Legends champs are great champions. Both champs have their strengths, weaknesses, and counters. In the game's current meta, Zac usually wins when trying to fight Karthus, with a 57.1% win rate. Therefore, Zac makes a fantastic counter for Karthus.
While Zac does have a much higher win rate compared to Karthus, when they face off with one another, Zac also has a greater level of difficulty that makes him a more difficult champion to pick up and master. You don't need to be too worried when picking Zac into Karthusas his relative depth means you may not be able to unleash his full potential without a lot of practice beforehand.
Additionally, Zac has some amount of utility and CC, a similar amount to Karthus. This makes her just as valuable during teamfights, especially when trying to counter champions with a lot of burst damage.
While there is not a single best champion overall in League of Legends, in Zac vs Karthus matchups, Zac is the better champion with a noticably higher win rate, more champion depth, and a similar amount of utility to help out your allies during teamfights.
Zac is a great counter to Karthus. Make sure you focus your actions on maximizing your gold income and clearing objectives. If you are able to do that, you should be able to stand on your own as Zac against Karthus.
To truly master Zac in order to counter Karthus during both the lane and mid / late game phases of League of Legends, you should continue reading to gather a few extra lessons on this matchup. If you mind the build and tips presented here, you will increase your win rate significantly and be that much closer to League of Legends pro players.
Zac typically gets less CS compared to Karthus. Champs who on average don't take many minion kills typically don't need much CS to be valuable teammates, such as support champions. They are able to scale properly off of their abilities and first items alone. Yet, champs with a lot of CS, such as hyper-carries, typically have to have several high cost items to be effective. In either situation, try to exceed the values displayed here to do well.
The best items to have in your Zac versus Karthus build consist of Spirit Visage, Sunfire Aegis, and Thornmail. When Zac bought at least these three pieces in his build, he performed much better against Karthus than with many other commonly used builds. In fact, Zac had an average winrate of 57.1% when countering Karthus with these items in his kit.
To have the greatest probability of defeating Karthus as Zac, you should equip the Aftershock, Font of Life, Conditioning, Revitalize, Triumph, and Legend: Tenacity runes from the Resolve and Precision rune sets. Of all the rune sets players chose for Zac vs Karthus battles, this mixture of runes resulted in the greatest win rate. In fact, these runes averaged a 57.1% win rate overall.
By default, tips, statistics, and builds on how to beat Karthus as Zac are displayed for all ranked divisions combined. If you would like to filter the stats and builds to a particular player tier, you can use the selection menu earlier on the page.