Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Storing a stun for use with her ultimate can turn the tide of a team fight.
Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
The Annie Kai'Sa synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Kai'Sa, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Annie sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Kai'Sa. His KDA fell from NaN to NaN. This decrease shows that Kai'Sa helps Annie perform not as well in ranked League games. Yet, the small difference indicates that this performance change is only marginal.
When Annie is paired with Kai'Sa, she sees a little increase in her complete damage output. This difference could signal that Kai'Sa provides protection for her to deal more damage or that her allyship also helps extend the round's duration. Similarly, when Annie is played with Kai'Sa on the same side, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing with Kai'Sa.
Additionally, when Annie plays with Kai'Sa on the same team, she on average takes a little more damage than when she fights alone. Taking more damage may indicate that Kai'Sa does a poor job of covering Annie during team fights.
There is no top ally for Annie that will always be her #1 synergy. Yet, Kai'Sa is a relatively poor ally for Annie. By locking into the same team as Annie, she lowers their win rate by -1.8% to 47.5%. This demonstrates that there is a negative synergy between Annie and Kai'Sa that allows them to perform not as well together than alone.
Kai'Sa has a lower difficulty than Annie. That means you don't need to be very careful when arranging Kai'Sa comrades to fight alongside, as they will have to have a lower level of skill to play well with you.
Playing together, you should see an overall large increase in your team’s capability to to do a lot of AP damage. When paired, these champs can blast through enemies with magic damage.
In contrast, by pairing Annie and Kai'Sa together, you probably will not be providing your team enough crowd control. Plan to include other champions on your team that helps cover this relative disparity in this pairing's abilities.
Regardless of the ability of your Kai'Sa ally, you need to focus on increasing your income, warding to avoid ambushes, and clearing objectives. If you do this, you should do well anyway.
If you would like to learn all of the intricacies of Annie to work well with Kai'Sa during both the laning and mid / late game phases of LoL rounds, you should keep reading to pick up some more lessons on this champion pairing. If you listen to the build and tips displayed here, you will grow your win rate significantly.
The most important items to use in your Annie and Kai'Sa synergy build include Void Staff, Shadowflame, and Stormsurge. When Annie incorporated at least these three finished items in her build, she did much better when paired up with Kai'Sa than with most other typical builds. In fact, Annie boasted an average winrate of 47.5% when synergizing her build and playstyle to Kai'Sa with this build.
To have the highest probability of coming out on top against your oponents, you should use the Electrocute, Cheap Shot, Eyeball Collection, Relentless Hunter, Manaflow Band, and Absolute Focus runes from the Domination and Sorcery rune sets. Out of all the runes players chose for this champion pairing, this mixture of runes yielded the best win rate. In fact, these runes averaged a 47.5% win rate overall.
By default, tips, stats, and builds on how to synergize Kai'Sa with Annie are presented for every ranked division. If you would like to narrow the stats and builds to a specific skill level, you may use the selection menu located earlier in the counter matchup guide.