Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Storing a stun for use with her ultimate can turn the tide of a team fight.
The Kai'Sa Annie synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Annie, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Kai'Sa sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Annie. His KDA went down from NaN to NaN. This fall shows that Annie helps Kai'Sa perform not as well in ranked League of Legends matches. Yet, the small difference shows that this performance change is not very impactful.
When Kai'Sa is an ally to Annie, she sees a little increase in her full damage dealt. This change could signal that Annie helps provide cover for her to deal more damage or that her allyship also helps extend the game's duration. Similarly, when Kai'Sa is played alongside Annie on the same side, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing synergisticly with Annie.
Moreover, when Kai'Sa plays with Annie on the same side, she on average receives a little less damage than when she plays alone. Taking not as much damage could indicate that Annie does a decent job of covering Kai'Sa in teamfights.
There is no top companion for Kai'Sa that will 100% of the time be her best ally. However, Annie is a decent ally for Kai'Sa. By being on the same side as Kai'Sa, she increases their win rate by 1.0% to 47.5%. This demonstrates that there is a potentially meaningful bond between Kai'Sa and Annie that allows them to perform stronger together than without each other.
Annie has a lower difficulty than Kai'Sa. That means you don't need to be cautious when lining up Annie comrades to go into battle on the same side as, as they will need a relatively low level of skill to do well with you.
Fighting together, you should expect to observe an overall large increase in your team’s capacity to deal magic damage. Together, these champs can deal quite a lot of AP type damage.
In contrast, by bringing Kai'Sa and Annie together, you will not be giving your side much support. Plan to bring other champs on your team that fills this relative gap in their abilities.
Regardless of the ability of your Annie teammate, you need to focus on increasing your gold income, warding to avoid ambushes, and taking down objectives. If you follow these simple suggestions, you will do well anyway.
If you would like to learn all of the intricacies of Kai'Sa to work well with Annie during both the lane and mid / late game phases of League of Legends matches, you should keep reading to learn a few extra tips and tricks for this champion pairing. If you use the build and suggestions shown above, you should increase your win rate significantly.
The ideal finished items to focus on in your Kai'Sa and Annie synergy build include Nashor's Tooth, Terminus, and Kraken Slayer. When Kai'Sa included at least these three great items in her build, she performed significantly better when fighting alongside Annie than with many other typical builds. In fact, Kai'Sa had an average winrate of 47.5% helping carry Annie with these items in her kit.
To have the greatest likelihood of coming out on top against your oponents, you should use the Hail of Blades, Taste of Blood, Eyeball Collection, Treasure Hunter, Biscuit Delivery, and Magical Footwear runes from the Domination and Inspiration rune sets. Out of all the rune sets that we analyzed for Kai'Sa and Annie pairings, this mix of runes resulted in the greatest win rate. Notably, these runes gave a 47.5% win rate overall.
If you would like to get Kai'Sa and Annie collaboration tips and stats for a a distinct player tier, feel free to choose one from the selection menu displayed above. At first, the stats and guides given are computed using every game finished with both champs.