Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The Kai'Sa Cassiopeia synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Cassiopeia, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Kai'Sa sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Cassiopeia. His KDA fell from NaN to NaN. This decrease shows that Cassiopeia helps Kai'Sa perform poorer in ranked League rounds. Yet, the small difference proves that this performance change is only marginal.
When Kai'Sa tries to synergize with Cassiopeia, she sees a barely noticable drop in her total damage output. This could demonstrate that Cassiopeia doesn't help cover for her to dish out more damage or that her participation also helps extend the game's duration. Similarly, when Kai'Sa is played together with Cassiopeia on the same side, he usually scores many fewer killing sprees than when she plays on his own. This is contrasting evidence that she is worse when playing alongside Cassiopeia.
Moreover, when Kai'Sa plays with Cassiopeia on the same team, she often takes a little less damage than when she fights alone. Getting dealt not as much damage could indicate that Cassiopeia does a decent job of protecting Kai'Sa in team fights.
There is no ideal champion pairing for Kai'Sa that will 100% of the time be her best synergy. However, Cassiopeia is a very typical ally for Kai'Sa. By playing on the same side as Kai'Sa, she improves their win rate by 0.8% to 47.3%. This signals that there is only a small strategic relationship between Kai'Sa and Cassiopeia that allows them to perform better together than without each other.
Cassiopeia has a much greater difficulty compared to Kai'Sa. That means Kai'Sa players need to be very careful when finding Cassiopeia comrades to go into battle on the same side as, as they will need a much greater level of skill to cooperate well with you.
Fighting on the same side, you should witness an overall large increase in your team’s capacity to deal magic damage. When paired, these two are able to dish out a surprising amount of magic type damage.
Although, by bringing Kai'Sa and Cassiopeia together, you probably will not be granting your other allies much support. Plan to pick other champs on your team that fills this gap in this pairing's kit.
Regardless of your Cassiopeia ally's skill level, you should focus on maximizing your income, staying alive by avoiding foolish fights, and taking down objectives. If you heed this simple advice, you will do well anyway.
To truly master Kai'Sa to pair well with Cassiopeia during both the early game and mid / late game phases of League games, you should continue reading to learn some more tricks and insights into this champion pairing. If you listen to the build and tips shown above, you will grow your win rate significantly.
The ideal finished items to have in your Kai'Sa and Cassiopeia synergy build include Wit's End, Guinsoo's Rageblade, and Terminus. When Kai'Sa incorporated at least these three finished items in her build, she did significantly better as an ally of Cassiopeia than with many other typical item sets. In fact, Kai'Sa boasted an average winrate of 47.3% when playing alongside Cassiopeia with this build.
To have the best probability of defeating your oponents, Kai'Sa players should use the Lethal Tempo, Presence of Mind, Legend: Bloodline, Coup de Grace, Biscuit Delivery, and Magical Footwear runes from the Precision and Inspiration rune sets. Out of all the rune sets that we analyzed for Kai'Sa and Cassiopeia pairings, this combination of runes yielded the best win rate. Moreover, these runes provided a 47.3% win rate overall.
By default, tips, statistics, and builds on how to pair Cassiopeia with Kai'Sa are given for all skill levels, merged. If you want to filter the stats and builds to a particular skill level, you should use the selection menu above.