Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Storing a stun for use with her ultimate can turn the tide of a team fight.
The Karthus Annie synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Annie, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Annie. His KDA fell from NaN to NaN. This decrease shows that Annie helps Karthus perform worse in competitive League of Legends matches. Yet, the small difference demonstrates that this performance change is only marginal.
When Karthus is paired with Annie, he sees a barely noticable drop in his full damage dealt. This change could indicate that Annie does not help protection for him to dish out more damage or that her support also helps extend the match's duration. Similarly, when Karthus is played with Annie on the same team, he usually scores many fewer killing sprees compared to when he plays alone. This is contrasting evidence that he is worse when playing alongside Annie.
Moreover, when Karthus plays with Annie on the same side, he often takes a little more damage than when he plays alone. Taking more damage may indicate that Annie does a poor job of protecting Karthus during teamfights.
There is no perfect ally for Karthus that will always be his best ally. Yet, overall, Annie is a very typical ally for Karthus. By playing on the same team as Karthus, she raises their win rate by 0.8% to 48.1%. This demonstrates that there is not really a strong synergy between Karthus and Annie that results in them performing at the top of their game together than without each other.
Annie has a lower difficulty than Karthus. That means Karthus players don't need to be careful when arranging Annie comrades to go into battle on the same side as, as they will need a relatively low level of skill to work well with you.
Fighting on the same side, Karthus players should see an overall large increase in your team’s capability to deal magical damage. When paired, these two can deal quite a lot of AP type damage.
Although, by bringing Karthus and Annie together, you may not be providing your other teammates a lot of AD. We recommend you include other champions on your team that nullifies this relative hole in this pairing's kit.
Regardless of your Annie ally's skill level, you need to focus on increasing your income, staying alive by avoiding foolish fights, and taking down objectives. If you heed this simple advice, you will do well anyway.
If you would like to truly master Karthus in order to work well with Annie during both the early game and mid / late game phases of League of Legends games, you should continue reading to learn additional tricks and insights into this champion pairing. If you use the build and suggestions shown here, you should increase your win rate by a lot.
The most important finished items to get in your Karthus and Annie synergy build consist of Malignance, Stormsurge, and Liandry's Torment. When Karthus bought at least these three great items in his build, he performed significantly better when paired up with Annie than with most other typical builds. In fact, Karthus boasted an average winrate of 48.1% when playing alongside Annie with this build.
To have the best chance of vanquishing your oponents, you should use the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Eyeball Collection, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Of all the rune builds players chose for Karthus and Annie pairings, this mix of runes yielded the top win rate. Notably, these runes provided a 48.1% winrate overall.
If you want to get Karthus with Annie synergy tips and builds for a an individual division rank, please select one from the selection menu provided above. At first, the stats and strategies shown are calculated using all games with data with these champs.