Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Communication is key when making use of Thresh's lantern. Let your teammates know how you like to use it.
Death Sentence and Flay can be combined in either cast order for powerful combinations.
Thresh can collect souls without needing to kill units himself. Planning your map position to be near the most deaths will help to maximize soul collection.
The Karthus Thresh synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Thresh, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Karthus sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Thresh. His KDA went down from NaN to NaN. This fall shows that Thresh helps Karthus perform poorer in competitive League rounds. Yet, the small difference demonstrates that this performance change is not very impactful.
When Karthus is paired with Thresh, he sees a marginal improvement in his total damage output. This could signal that Thresh provides protection for him to dish out more damage or that his support also helps increase the game's duration. Similarly, when Karthus is played with Thresh on the same side, he usually scores many fewer killing sprees compared to when he plays without Thresh. This is contrasting evidence that he is worse when playing alongside Thresh.
Moreover, when Karthus plays with Thresh on the same team, he usually takes a little more damage than when he plays alone. Receiving more damage may indicate that Thresh does a poor job of covering Karthus during teamfights.
There is no perfect ally for Karthus that will 100% of the time be his best teammate. However, Thresh is a below average teammate for Karthus. By being on the same team as Karthus, he drops their win rate by -2.4% to 44.9%. This proves that there is a negative strategic relationship between Karthus and Thresh that allows them to perform worse together than alone.
Thresh has a lower difficulty than Karthus. That means Karthus players don't need to be very careful when arranging Thresh comrades to go into battle on the same side as, as they will require a relatively low level of skill to be able to cooperate well with you.
Fighting on the same side, you should expect to see an overall large increase in your team’s capability to deal magic damage. Together, these champs can deal quite a lot of AP type damage.
In contrast, by pairing Karthus and Thresh together, you may not be providing your team enough attack damage. We recommend you include other champions on your team that nullifies this relative gap in this pairing's abilities.
Regardless of the skill of your Thresh ally, you should focus on maximizing your income, warding to avoid ambushes, and taking down objectives. If you follow these simple suggestions, you will do well, regardless.
If you would like to truly master Karthus to work well with Thresh during both the lane and mid / late game phases of LoL games, you should continue reading to pick up additional lessons on this champion pairing. If you pay attention to the build and tips shown above, you will grow your win rate significantly.
The top finished items to use in your Karthus and Thresh synergy build consist of Shadowflame, Stormsurge, and Liandry's Torment. When Karthus bought at least these three items in his build, he did a lot better when paired up with Thresh than with most other common builds. In fact, Karthus boasted an average winrate of 44.9% helping carry Thresh with this build.
To have the greatest chance of annihilating your oponents, Karthus players should equip the Dark Harvest, Cheap Shot, Eyeball Collection, Ultimate Hunter, Presence of Mind, and Last Stand runes from the Domination and Precision rune sets. Out of all the rune builds that we analyzed for this team composition, this blending of runes resulted in the greatest win rate. Moreover, these runes averaged a 44.9% winrate overall.
By default, tips, stats, and builds on how to pair Thresh with Karthus are shown for all ranked divisions combined. If you want to narrow the stats and builds to a particular player tier, you can use the selection menu located earlier in the counter matchup guide.