Miss Fortune ramps up speed if she hasn't recently taken damage. Avoid getting hit to move very fast.
Use Double Up on the furthest enemy minion if enemy champions are hiding in back; it will bounce to them for lots of damage.
Make sure to utilize Love Tap while Strut is on cooldown to maximize the active's availability.
Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The Miss Fortune Vayne synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Vayne, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Miss Fortune sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Vayne. His KDA went down from NaN to NaN. This drop shows that Vayne helps Miss Fortune perform not as well in competitive LoL games. Yet, the small difference indicates that this performance change is only marginal.
When Miss Fortune is an ally to Vayne, she gets a small decrease in her complete damage output. This difference could signal that Vayne doesn't help cover for her to deal more damage or that her support also helps extend the round's duration. Similarly, when Miss Fortune is played together with Vayne on the same side, he usually scores many fewer killing sprees than when she plays on his own. This is contrasting evidence that she is worse when playing with Vayne.
Moreover, when Miss Fortune plays with Vayne on the same side, she usually takes a little less damage than when she plays alone. Receiving not as much damage may mean that Vayne does a decent job of protecting Miss Fortune in team fights.
There is no one best companion for Miss Fortune that will no matter what be her #1 synergy. However, Vayne is a relatively poor teammate for Miss Fortune. By playing on the same side as Miss Fortune, she drops their win rate by -1.9% to 51.5%. This shows that there is a bad bond between Miss Fortune and Vayne that allows them to perform worse together than without each other.
Vayne has a much greater difficulty compared to Miss Fortune. That means you need to be careful when arranging Vayne allies to play with, as they will need a much greater level of skill to fight well with you.
Playing together, you should witness an overall large increase in your team’s ability to dish out massive AD. When paired, these champs should be able to take down targets with auto-attacks and other AD damage abilities.
In contrast, by aligning Miss Fortune and Vayne together, you probably will not be granting your side very much protection for burst damage. Plan to have other champs on your team that neutralizes this relative hole in their playstyle.
Regardless of the skill of your Vayne teammate, you should focus on maximizing your income, outlasting your enemies, and taking down objectives. If you follow these simple suggestions, you will do well, regardless.
If you would like to truly master Miss Fortune to work well with Vayne during both the laning and mid / late game phases of LoL games, you should continue reading to gather some more tips and tricks for this champion pairing. If you mind the build and stats displayed above, you will increase your win rate by a lot.
The best finished items to use in your Miss Fortune and Vayne synergy build include Guardian Angel, Edge of Night, and Serylda's Grudge. When Miss Fortune included at least these three items in her build, she performed a lot better as an ally of Vayne than with most other commonly used builds. In fact, Miss Fortune boasted an average winrate of 51.5% when playing alongside Vayne with this build.
To have the highest probability of annihilating your oponents, you should take the First Strike, Magical Footwear, Biscuit Delivery, Cosmic Insight, Absolute Focus, and Gathering Storm runes from the Inspiration and Sorcery rune sets. Out of all the rune sets that we analyzed for this champion pairing, this order of runes resulted in the top win rate. Notably, these runes averaged a 51.5% winrate overall.
By default, tips, stats, and builds on how to synergize Vayne with Miss Fortune are presented for all skill levels, merged. If you would like to filter the statistics and builds to a distinct player tier, you can use the selection menu located earlier on the page.