Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The Senna Cassiopeia synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Cassiopeia, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Senna sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Cassiopeia. His KDA went down from NaN to NaN. This negative change shows that Cassiopeia helps Senna perform not as well in ranked LoL rounds. Yet, the small difference shows that this performance change is only marginal.
When Senna is an ally to Cassiopeia, she observes a marginal improvement in her complete damage dealt. This difference could demonstrate that Cassiopeia supports by providing protection for her to dish out more damage or that her presence also helps increase the round's duration. Similarly, when Senna is played together with Cassiopeia on the same team, he usually scores many fewer killing sprees compared to when she plays alone. This is contrasting evidence that she is worse when playing synergisticly with Cassiopeia.
Additionally, when Senna plays with Cassiopeia on the same side, she on average receives a little less damage than when she fights alone. Taking not as much damage could indicate that Cassiopeia does a decent job of protecting Senna during teamfights.
There is no one best ally for Senna that will no matter what be her #1 ally. However, Cassiopeia is a pretty good teammate for Senna. By being on the same side as Senna, she improves their win rate by 2.1% to 52.9%. This shows that there is pretty good bond between Senna and Cassiopeia that results in them performing at the top of their game together than alone.
Cassiopeia has a greater difficulty than Senna. That means you need to be very careful when enlisting Cassiopeia comrades to fight alongside, as they will need a greater level of skill to be able to work well with you.
Working together, Senna players should observe an overall large increase in your team’s capability to deal magical damage. Together, these champs can blast through enemies with magic damage.
Although, by pairing Senna and Cassiopeia together, you may not be providing your other teammates a lot of protection for burst damage. Plan to include other champions on your team that nullifies this relative disparity in their capabilities.
Regardless of the skill of your Cassiopeia teammate, you should focus on maximizing your gold income, staying alive by avoiding foolish fights, and taking down objectives. If you do this, you should do well anyway.
If you would like to truly master Senna in order to synergize with Cassiopeia during both the lane and mid / late game phases of League of Legends, you should continue reading to master additional tips and tricks for this champion pairing. If you mind the build and stats displayed here, you should increase your win rate by a lot.
The most crucial items to have in your Senna and Cassiopeia synergy build consist of Rapid Firecannon, Bloodsong, and Voltaic Cyclosword. When Senna incorporated at least these three pieces in her build, she performed a lot better when fighting alongside Cassiopeia than with many other common item sets. In fact, Senna boasted an average win rate of 52.9% helping carry Cassiopeia with this build.
To have the best chance of crushing your oponents, you should take the Fleet Footwork, Presence of Mind, Legend: Alacrity, Cut Down, Approach Velocity, and Biscuit Delivery runes from the Precision and Inspiration rune sets. Out of all the rune combinations players chose for Senna and Cassiopeia pairings, this combination of runes yielded the greatest win rate. Moreover, these runes averaged a 52.9% win rate overall.
By default, tips, stats, and builds on how to pair Cassiopeia with Senna are displayed for all ranked divisions. If you would like to narrow the stats and builds to a particular skill level, you may use the selection menu located earlier on the page.