Spider Form is most effective at finishing off enemies with low health; Human Form's Neurotoxin does more damage to healthy foes.
Elise's Spider Form and Spider Form abilities do not cost mana and can be prioritized when you are trying to conserve mana.
When in Spider Form, Spiderlings will attack the target that Elise uses Venomous Bite on.
The Seraphine Elise synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Elise, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Seraphine sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Elise. His KDA fell from NaN to NaN. This decrease shows that Elise helps Seraphine perform worse in competitive League rounds. Yet, the small difference demonstrates that this performance change is not very impactful.
When Seraphine is an ally to Elise, she observes a little decrease in her complete damage output. This change may demonstrate that Elise does not support by providing protection for her to dish out more damage or that her participation also helps extend the round's duration. Similarly, when Seraphine is played together with Elise on the same team, he usually scores many fewer killing sprees than when she plays on his own. This is contrasting evidence that she is worse when playing with Elise.
Additionally, when Seraphine plays with Elise on the same side, she on average receives a little more damage than when she fights alone. Getting dealt more damage could mean that Elise does a poor job of protecting Seraphine in teamfights.
There is no one best synergy for Seraphine that will no matter what be her ideal teammate. However, overall, Elise is a below average companion for Seraphine. By locking into the same side as Seraphine, she drops their win rate by -1.9% to 48.1%. This clearly indicates that there is a negative synergy between Seraphine and Elise that results in them performing worse together than without each other.
Elise has a much greater difficulty compared to Seraphine. That means you need to be very careful when enlisting Elise comrades to fight alongside, as they will require a much higher level of skill to be able to play well with you.
Working cooperatively, you should observe an overall large increase in your team’s capacity to buff allies and debuff enemies. Together, these champions should be able to manipulate the pace of team fights.
Conversely, by pairing Seraphine and Elise together, you probably will not be granting your team a lot of cover. Make sure to bring other champs on your team that neutralizes this hole in this pairing's abilities.
Regardless of the skill of your Elise ally, you need to focus on increasing your income, staying alive by avoiding foolish fights, and clearing objectives. If you do this, you should do well, regardless.
If you would like to truly master Seraphine in order to work well with Elise during both the early game and mid / late game phases of LoL games, you should continue reading to master a few extra tips and tricks for this champion pairing. If you listen to the build and suggestions shown here, you will grow your win rate by a lot.
The most important finished items to focus on in your Seraphine and Elise synergy build include Celestial Opposition, Staff of Flowing Water, and Moonstone Renewer. When Seraphine combined at least these three pieces in her build, she performed much better as an ally of Elise than with most other typical builds. In fact, Seraphine had an average winrate of 48.1% helping carry Elise with these items in her kit.
To have the highest probability of annihilating your oponents, Seraphine players should equip the Summon Aery, Manaflow Band, Transcendence, Scorch, Bone Plating, and Revitalize runes from the Sorcery and Resolve rune sets. Out of all the rune builds players picked for this champion pairing, this mix of runes yielded the top win rate. In fact, these runes provided a 48.1% win rate overall.
By default, tips, stats, and builds on how to synergize Elise with Seraphine are shown for all skill levels, merged. If you would like to scope the stats and builds to an individual division, you should use the selection menu located earlier on the page.