You can set her passive to use hotkeys in the options menu. The default is Shift+F1~F5
Try to use Inherent Glamour sparingly, ineffective uses will put enemies on the alert.
The Sett Neeko synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Neeko, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Sett sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Neeko. His KDA worsened from NaN to NaN. This negative change shows that Neeko helps Sett perform not as well in competitive LoL rounds. Yet, the small difference indicates that this performance change is not very impactful.
When Sett plays on the same team as Neeko, he sees a small increase in his complete damage dealt. This difference could demonstrate that Neeko helps provide protection for him to deal more damage or that her allyship also helps increase the game's duration. Similarly, when Sett is played alongside Neeko on the same side, he usually scores many fewer killing sprees than when he plays without Neeko. This is contrasting evidence that he is worse when playing with Neeko.
Moreover, when Sett plays with Neeko on the same side, he on average takes a little more damage than when he plays alone. Receiving more damage could mean that Neeko does a poor job of protecting Sett during teamfights.
There is no one best companion for Sett that will 100% of the time be his ideal synergy. Yet, Neeko is a not very good teammate for Sett. By playing on the same team as Sett, she drops their win rate by -1.4% to 49.1%. This proves that there is a harmful strategic relationship between Sett and Neeko that results in them performing worse together than alone.
Neeko has a greater difficulty than Sett. That means you should be cautious when finding Neeko allies to fight alongside, as they will need a greater level of skill to be able to work well with you.
Playing cooperatively, Sett players should witness an overall large increase in your team’s capability to deal magic damage. Combined, these two can blast through enemies with magic damage.
In contrast, by pairing Sett and Neeko together, you probably will not be giving your team a great deal of engage potential. Plan to pick other champions on your team that neutralizes this relative gap in their potential.
Regardless of your Neeko ally's skill level, you should focus on maximizing your gold income, warding to avoid ambushes, and taking down objectives. If you do this, you will do well, regardless.
To truly master Sett in order to synergize with Neeko during both the lane and mid / late game phases of League rounds, you should keep reading to gather additional tricks and insights into this champion pairing. If you use the build and tips displayed here, you will increase your win rate by a lot.
The ideal items to get in your Sett and Neeko synergy build include Blade of The Ruined King, Titanic Hydra, and Sundered Sky. When Sett used at least these three finished items in his build, he did a lot better when paired up with Neeko than with most other common builds. In fact, Sett had an average win rate of 49.1% helping carry Neeko with this build.
To have the greatest chance of coming out on top against your oponents, Sett players should equip the Lethal Tempo, Triumph, Legend: Alacrity, Last Stand, Second Wind, and Unflinching runes from the Precision and Resolve rune sets. Out of all the rune builds players used for Sett and Neeko pairings, this mix of runes yielded the best win rate. Notably, these runes averaged a 49.1% win rate overall.
If you want to get Sett with Neeko cooperations tips and builds for a a particular division, feel free to select one from the selection menu provided above. At first, the statistics and build suggestions given are computed using all rounds completed with both champs.