Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Seeds grant vision to your team.
Placing a seed in your spell's path after you have cast it gives you the best chance of having a seed in the proper spot.
Zyra is a great ambusher - look for opportunities to set a trap of seeds in brush, then lure enemies in.
The Vayne Zyra synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Zyra, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Vayne sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Zyra. His KDA fell from NaN to NaN. This worsening shows that Zyra helps Vayne perform poorer in ranked League of Legends games. Yet, the small difference indicates that this performance change is not very impactful.
When Vayne tries to synergize with Zyra, she gets a barely noticable drop in her full damage dealt. This change could indicate that Zyra doesn't help cover for her to deal more damage or that her allyship also helps increase the match's duration. Similarly, when Vayne is played with Zyra on the same side, he usually scores many fewer killing sprees than when she plays without Zyra. This is contrasting evidence that she is worse when playing with Zyra.
Moreover, when Vayne plays with Zyra on the same team, she usually takes a little more damage than when she plays alone. Taking more damage may mean that Zyra does a poor job of covering Vayne during team fights.
There is no universally accepted best companion for Vayne that will always be her best synergy. Yet, Zyra is a pretty good teammate for Vayne. By locking into the same team as Vayne, she improves their win rate by 2.5% to 52.8%. This shows that there is a potentially meaningful bond between Vayne and Zyra that allows them to perform at the top of their game together than alone.
Zyra has a lower difficulty than Vayne. That means you don't need to be careful when lining up Zyra teammates to play with, as they will require a relatively low level of skill to cooperate well with you.
When playing together, Vayne players should expect to witness an overall large increase in your team’s ability to deal physical damage. Together, these two can tear through the other team with a lot of physcial damage.
Although, by grouping Vayne and Zyra together, you probably will not be giving your other allies much cover. Make sure to pick other champs on your team that nullifies this gap in this pairing's playstyle.
Regardless of the skill of your Zyra teammate, you need to focus on increasing your gold income, warding to avoid ambushes, and clearing objectives. If you follow these simple suggestions, you should do well anyway.
If you would like to truly master Vayne to synergize with Zyra during both the laning and mid / late game phases of League of Legends games, you should keep reading to master some more tips and tricks for this champion pairing. If you pay attention to the build and stats presented above, you will grow your win rate by a lot.
The most important finished items to build first in your Vayne and Zyra synergy build include Experimental Hexplate, Guinsoo's Rageblade, and Blade of The Ruined King. When Vayne incorporated at least these three finished items in her build, she performed significantly better when fighting alongside Zyra than with many other common item sets. In fact, Vayne boasted an average win rate of 52.8% when synergizing her build and playstyle to Zyra with these items in her kit.
To have the best chance of vanquishing your oponents, you should use the Fleet Footwork, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Of all the runes that we analyzed for this team composition, this composite of runes yielded the greatest win rate. Notably, these runes provided a 52.8% winrate overall.
If you want to view Vayne with Zyra collaboration tips and builds for a a distinct rank, feel free to choose one from the selection menu provided above. If viewing for the first time, the stats and tips and suggestions shown are calculated using every game with data with both champs.